Over medium heat use a large saucepan to heat olive oil.
Add chopped onions and sauté until they become translucent, about 5 minutes.
Add the minced garlic and sauté for an extra 1-2 minutes until it is fragrant.
Pour in the red wine and allow it to simmer until it's reduced by half, about 5 minutes.
Crush the whole peeled tomatoes with your hands or a wooden spoon and add them to the saucepan along with their juices.
Season with dried oregano, dried basil, salt, pepper, and a pinch of red pepper flakes if you prefer a bit of heat. Stir to combine.
Reduce the heat to low and let the sauce simmer, uncovered, for 2 hours, stirring occasionally. The sauce should thicken and intensify in flavor.
Taste and adjust the seasoning if necessary.
Serve the Sicilian Sugo over your favorite pasta, garnished with fresh basil leaves and a sprinkle of Pecorino Romano cheese, if desired.